I can’t believe how many months I procrastinated in writing this blog post. Among deadlines and diaper changes, it just took me that much time to put my thoughts in order regarding a part of aging that I thought was crystal clear: aging leads to slow clearance therefore autophagy induction must always be a good […]
This blog post is not an argument for reductionism. Instead, it is an argument for speeding up treatments that work in the case of a complex disease like aging. While demand for such treatments exists, anti-aging clinical trials are extremely rare. Elderly patients are the most complex ones of all – it is what intellectually […]
One of the most disturbing symptoms that occur with aging is rigidity. Humans become stiffer with age, not only in mentality but also physically. Flexibility is in short supply with age as fibroblasts get activated for any tiny injury and respond by excessively depositing extracellular matrix components. For this reason alone, fibrosis – especially excessive […]
During my previous post I mentioned how the evolutionary theory of aging was tested empirically by selective breeding of fruit flies for longevity and later on for shorter lifespans. The longer lived fruit flies obtained in the lab got the nickname of Methuselah flies. Displaying a longer mean and maximum lifespan, they expressed hundreds of […]