I can’t believe how many months I procrastinated in writing this blog post. Among deadlines and diaper changes, it just took me that much time to put my thoughts in order regarding a part of aging that I thought was crystal clear: aging leads to slow clearance therefore autophagy induction must always be a good […]
negligible senescence
Posted in Calorie restriction with optimal nutrition, Comparative gerontology, Out-of-the-box thinking, Slowing aging
How to play with evolution in the lab to create longer-lived animals
I was a college student when I first stumbled upon the “Ending Aging” book by Dr. Aubrey de Grey. I read that book cover to cover but I never got highly enthusiastic about SENS since there were important details which didn’t make sense. The types of damage that humans incur as they age are excellently […]
When I wrote ‘The aging gap between species’, the longest living vertebrate was the bowhead whale at 211 years old. The latter still holds the record for the longest living mammal, but these days the vertebrate record is held by the Greenland shark at 392 years. Determining age in bony fish is done by counting […]
Posted in Comparative gerontology
Immunotherapy for senescent cell removal – lessons from human embryo development and other species
For a long time I had this simplistic view that senescent cells accumulate with age, contributing to many age-related degenerative diseases through the sterile inflammation and regeneration impairment they cause. I also thought their removal with the help of drugs is the only possible solution to get rid of them. Destroying senescent cells shouldn’t be […]