I was a college student when I first stumbled upon the “Ending Aging” book by Dr. Aubrey de Grey. I read that book cover to cover but I never got highly enthusiastic about SENS since there were important details which didn’t make sense. The types of damage that humans incur as they age are excellently…… Continue reading How to play with evolution in the lab to create longer-lived animals
Tag: senescence
Immunotherapy for senescent cell removal – lessons from human embryo development and other species
For a long time I had this simplistic view that senescent cells accumulate with age, contributing to many age-related degenerative diseases through the sterile inflammation and regeneration impairment they cause. I also thought their removal with the help of drugs is the only possible solution to get rid of them. Destroying senescent cells shouldn’t be…… Continue reading Immunotherapy for senescent cell removal – lessons from human embryo development and other species
How to avoid the adverse reactions of senolytics through better design
There is no coincidence that cancer is more frequent as we age. And it is also no coincidence that many anti-aging therapies destined for rejuvenation could allow unleashed growth to take place and cause cancer. Hence my interest in those species which despite an abundant capability to regenerate their damaged tissues, show no increased rate…… Continue reading How to avoid the adverse reactions of senolytics through better design
Aging is the loss of cell polarity maintenance
There are 2 ways to deal with the inevitable damage that takes place in an organism in time: 1. You can try to repair it. 2. You can try to limit it. The first solution is usable, but expensive. Energetically expensive. Species mainly use it on the short-term. Some kind of repair is needed for…… Continue reading Aging is the loss of cell polarity maintenance