Longevity and the Compound Effect

Rome wasn’t built in a day and neither is longevity attained overnight. A few years ago I read about the compound effect: it’s this idea that baby steps done regularly lead to extraordinary results on the long term. Exponential growth is very hard for humans to wrap their minds around. Linear growth is so much…… Continue reading Longevity and the Compound Effect

Career choice, early retirement and longevity

I could have picked any specialty years ago after I passed the residency exam, but I chose geriatrics to the shock of everyone. I wanted to have the specialty with the wisest patients and even if I’m not practicing it anymore for reasons I’ll detail below, I don’t regret anything. It was impossible for elderly…… Continue reading Career choice, early retirement and longevity

Aging is the loss of cell polarity maintenance

There are 2 ways to deal with the inevitable damage that takes place in an organism in time: 1. You can try to repair it. 2. You can try to limit it. The first solution is usable, but expensive. Energetically expensive. Species mainly use it on the short-term. Some kind of repair is needed for…… Continue reading Aging is the loss of cell polarity maintenance

How to engineer negligible senescence in humans – part IV GlycoSENS

Source: http://www.taste.com.au/images/recipes/tas/2012/04/28800_l.jpg

Have you ever started from one of these: and obtained these? This is exactly what happens in our bodies as we age, the only difference being that it takes place in decades instead of hours. Chemically it is called the Maillard reaction. What are extracellular crosslinks and how do they form? We burn slowly and…… Continue reading How to engineer negligible senescence in humans – part IV GlycoSENS