I can’t believe how many months I procrastinated in writing this blog post. Among deadlines and diaper changes, it just took me that much time to put my thoughts in order regarding a part of aging that I thought was crystal clear: aging leads to slow clearance therefore autophagy induction must always be a good…… Continue reading Eaten alive: the double-edged sword of autophagy
Tag: longevity letter blog
3 Ways You Can Tackle Age-related Fibrosis
One of the most disturbing symptoms that occur with aging is rigidity. Humans become stiffer with age, not only in mentality but also physically. Flexibility is in short supply with age as fibroblasts get activated for any tiny injury and respond by excessively depositing extracellular matrix components. For this reason alone, fibrosis – especially excessive…… Continue reading 3 Ways You Can Tackle Age-related Fibrosis
How targeting multiple aging pathways doubled the maximum lifespan of fruit flies
During my previous post I mentioned how the evolutionary theory of aging was tested empirically by selective breeding of fruit flies for longevity and later on for shorter lifespans. The longer lived fruit flies obtained in the lab got the nickname of Methuselah flies. Displaying a longer mean and maximum lifespan, they expressed hundreds of…… Continue reading How targeting multiple aging pathways doubled the maximum lifespan of fruit flies
Immunotherapy for senescent cell removal – lessons from human embryo development and other species
For a long time I had this simplistic view that senescent cells accumulate with age, contributing to many age-related degenerative diseases through the sterile inflammation and regeneration impairment they cause. I also thought their removal with the help of drugs is the only possible solution to get rid of them. Destroying senescent cells shouldn’t be…… Continue reading Immunotherapy for senescent cell removal – lessons from human embryo development and other species